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Research programme 02
Cell fate and adaptive homeostasis
We investigate how p53-isoform balance influences apoptosis, senescence, proliferation, DNA repair and tissue regeneration.
This research connects p53-isoform expression with replicative senescence, proliferation, apoptosis, DNA repair, development and regeneration.
The broader concept is adaptive homeostasis: cells and organisms continually adjust to stress while preserving function. Ageing, chronic damage and disease can disturb this balance.
